胰岛素样生长因子2 mRNA结合蛋白2(IGF2BP2)在肺癌发生发展中的作用研究
The role of insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) in the development of lung cancer
Abstract
背景:当今世界,癌症成为威胁人类健康的头号杀手,其中肺癌更是最常见的恶性肿瘤之一,由于其早期症状不明显,恶性程度高,发现时往往已是中晚期,其每年发病率和死亡率均位于所有癌症的前列。尽管手术方式和化学药物不断更新,但均不能达到较好的治疗效果,肺癌的发病率和死亡率仍没有降低的趋势。因此,早期发现、早期治疗成为治愈肺癌的关键。随着分子生物学的进展,肿瘤相关抗原(TAA)逐渐成为了现代医学的关注热点,因为它不仅能使肿瘤患者早期得到诊断,而且也为分子靶向治疗提供了分子基础。类胰岛素生长因子2mRNA结合蛋白(IGF2BP2)是一种细胞质蛋白,被证明和多种肿瘤的发生发展有关,如肝癌、乳腺癌、神经胶质瘤、食... Background: At present, cancer has become the leading threat to the health of mankind. The lung cancer is one of the most common malignant tumors worldwide. For the hidden symptoms and high malignant of initial lung cancer, it is always late when the disease is diagnosed and the morbidity and mortality rates are always at the top. Despite of continuous development of surgery and chemical drugs, th...