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牙龈卟啉单胞菌裂解液下调上皮细胞中整合素β6表达的分子机制
Molecular mechanism of down-regulated integrin β6 expression in epithelial cells by Porphyromonas gingivalis lysate

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牙龈卟啉单胞菌裂解液下调上皮细胞中整合素β6表达的分子机制.pdf (912.8Kb)
Date
2018-04-12
Author
冯筱凡
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  • 医学院-学位论文 [896]
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Abstract
目的:牙周炎主要是由牙周炎致病菌引起的一种慢性进行性侵犯及破坏牙龈和牙周组织的炎症性疾病,不仅是导致成年人牙齿丧失的主要原因,还能引起其他系统性疾病比如心血管疾病和全身性的炎症反应。牙龈卟啉单胞菌是牙周炎的主要致病菌,含有很多致病因子。整合素avβ6在炎症应答,组织损伤和修复时高表达,avβ6在成人上皮细胞中一般不表达,但在健康牙龈结合上皮中avβ6组成型表达,且当发生牙周炎时,人牙龈结合上皮中的avβ6的表达下调,但具体机制尚不清楚。整合素β6(ITGβ6)亚基只能与整合素αv亚基结合,是组成αvβ6的关键亚基,ITGβ6亚基的表达水平代表了αvβ6的表达水平。牙龈卟啉单胞菌是否参与人牙龈结...
 
Objective: Periodontitis is a chronic inflammatory disease mainly caused by the periodontitis pathogens that damage the gums and periodontal tissue. Periodontitis not only is the main cause of adult tooth loss, as well as other systemic diseases such as cardiovascular disease and systemic inflammatory response. Porphyromonas gingivalis is the main pathogen of periodontitis, containing a lot of pat...
 
URI
https://dspace.xmu.edu.cn/handle/2288/170831

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