慢性炎症小鼠通过海马DNA甲基化促进空间认知能力的研究

Abstract

慢性炎症存在于各种慢性疾病如糖尿病、肥胖、癌症、阿尔兹海默症、心血管疾病、代谢性疾病和缺氧性疾病，并在其发展中起到关键性的作用。然而，慢性炎症对脑功能有何影响及其机制尚不清楚。早期文献显示，炎症可以促进神经营养因子在神经系统内的分泌，进而保护神经元免受损伤；免疫机制也可以积极调节神经回路的重塑，促进记忆的巩固，海马长时程增强和神经发生。而在几种慢性炎症疾病中发现了DNA甲基化，DNA甲基化通过调节基因的表达和活性，影响细胞的增殖和分化，并且调节长时程记忆和突触可塑性。因此，本研究首先观察认知功能的变化及DNA甲基化和去甲基化参与的机制。 目的：通过构建不同严重程度的慢性炎症小鼠模型，运用行为...

Chronic inflammation is present in a variety of chronic diseases and plays a key role in the development of many chronic diseases such as diabetes, obesity, cancer, Alzheimer's disease, cardiovascular disease, metabolic diseases and hypoxic diseases. However, what's the effect of chronic inflammation on brain function and its mechanism is unclear. In previous studies, the secretion of neurotrophic...