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过表达Rab15对乳腺癌细胞生长和迁移的影响
Influence of Rab15 Overexpression on Growth and Migration of Breast Cancer Cells

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过表达Rab15对乳腺癌细胞生长和迁移的影响.pdf (997.5Kb)
Date
2018-04-09
Author
陈灵球
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  • 药学院-学位论文 [155]
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Abstract
Rab蛋白是Ras家族最大的家族成员,主要参与细胞内蛋白质的运输。其蛋白水平表达的高低及其GTPase活性的变化,都会导致相关细胞器工作的紊乱,致使机体发生病变,甚至诱发癌症。目前在哺乳动物中,已发现70多种Rab蛋白。我们深入研究了其中的大部分,并且取得了一定的成就,但关于Rab家族成员Rab15的研究报道甚少。本文拟探讨Rab15蛋白在细胞中的定位及其细胞生物学功能。 通过免疫荧光技术,标记不同细胞器的内源性Marker,发现Rab15定位于高尔基,且与内体和溶酶体没有明显的共定位。检测其蛋白水平表达情况,结果显示Rab15在高侵袭的乳腺癌细胞中表达量普遍较低。于是在高侵袭乳腺癌细胞MD...
 
Rab protein is the largest family within the Ras superfamily, and is involved in intracellular protein transport .The dysfunction of Rab proteins is related to many diseases. In mammals, more than 70 different RAB and RAB-like proteins have been characterized so far. Although we have studied most of these proteins and have achieved some success, one of Rab family members, Rab15 has not been invest...
 
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https://dspace.xmu.edu.cn/handle/2288/170813

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