多功能纳米粒子的构建及其抗脑胶质瘤研究
The construction of multifunctional nanoparticles and anti-glioblastoma research
Abstract
脑胶质瘤是最常见的中枢神经系统恶性肿瘤，由于其呈恶性浸润性生长，因此传统的治疗方式难以达到良好的治疗效果。光热治疗、光动力治疗、基因治疗等新型肿瘤治疗方式正逐步被应用到抗脑胶质瘤的研究中。但是单一的治疗方式始终难以实现彻底的治疗，因此，联合治疗成为脑胶质瘤治疗的新策略。 本课题构建了两种联合治疗的纳米粒递送系统，以期能够达到更好的脑胶质瘤治疗效果。首先以金纳米棒为核心，包覆二氧化硅，外侧连接近红外染料IR795，构建了AuNRs@SiO2-IR795被动靶向纳米粒子，实现光热和光动力的联合治疗。进一步采用阳离子脂质体包载金纳米棒、阿霉素和YAP-siRNA，以ANG2为靶标进行修饰，旨在构建... Glioma is the most common malignant tumors of the central nervous system. Due to its malignant invasive growth, it was different to achieve the better therapeutic effect. Nowadays, photothermal therapy, photodynamic therapy, gene therapy, et.al, was gradually being applied to antiglioma. But none of the single treatment could completely satisfy the clinical treatment. Therefore, the multimodal the...