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靶向表皮生长因子受体的嵌合抗原受体T细胞对脑胶质瘤细胞杀伤作用的研究
The Cytotoxicity of Anti-EGFR Chimeric Antigen Receptor T Cells for Glioma Cell Lines

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靶向表皮生长因子受体的嵌合抗原受体T细胞对脑胶质瘤细胞杀伤作用的研究.pdf (680.7Kb)
Date
2018-04-12
Author
阮君
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  • 药学院-学位论文 [374]
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Abstract
嵌合抗原受体(chimericantigenreceptor,CAR)T细胞疗法是一种过继性细胞免疫疗法。它利用病人自体T细胞在体外进行基因改造后回输到病人体内而起到特异性杀伤肿瘤细胞的作用。外源为T细胞添加的CAR蛋白使T细胞获得了新的功能活性,可以特异性识别肿瘤细胞表面的相关抗原,并直接活化T细胞,而不受主要组织相容性复合物(majorhistocompatibilitycomplex,MHC)和共刺激分子的限制。脑胶质瘤是成年人中最常见,侵袭性最高的原发性颅内肿瘤。其发病机制尚不明确。采用传统手术联合术后化疗和放疗的患者多在治疗后数月复发,再次手术后复发的几率仍然很高。表皮生长因子受体(...
 
Chimeric antigen receptor (CAR) T cell therapy is a kind of adoptive cellular immunotherapy which use genetically modified autologous T cells to kill their own tumor cells specifically. The exogenous protein gives T cells a new active function: to identify tumor associated antigen on the surface specifically and active T cells directly, without major histocompatibility complex (MHC) and stimulatin...
 
URI
https://dspace.xmu.edu.cn/handle/2288/170809

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