核受体Nur77配体雷公藤红素新型分子作用机制研究
A Novel Mechanism Study of Celastrol the Ligand of Nur77
Abstract
雷公藤红素与青蒿素，雷公藤甲素，辣椒素和姜黄素一起在2007年被Cell杂志称为最有潜力实现转化的中医药化合物，越来越多研究表明了雷公藤红素在各种炎症性疾病中发挥强效的抗炎功能，同时也有研究表明雷公藤红素可以用于治疗肥胖这一代谢性疾病。但是，其具体的靶点和分子机制仍不十分清楚，这使得雷公藤红素的药物开发面临了极大的困难，寻找雷公藤红素的靶标和分子作用机制是相关研究工作者迫切需要解决的问题，也是本博士论文工作的重大价值和现实意义。 线粒体是细胞内氧化磷酸化和形成ATP的主要场所，细胞生命活动所需的95%的能量都来自于线粒体，因此有“动力工厂”之称。线粒体在细胞死亡，自噬，免疫和炎症中发挥着不可... Celatrol, artemisinin, triptolide, capsaicin and curcumin are considered as the promise of turning traditional medicines into modern drugs by Cell paper in 2007. Celastrol has attracted increasing interest recently and reported for its potent anti-inflammatory activities in many inflammatory diseases, including obesity. However, the specific target and the mechanism by which celastrol exert its be...