RXRα调控有丝分裂的分子机制研究
Investigating the mechanistic role of RXRα in mitotic regulation
Abstract
细胞周期(cellcycle)是指细胞从一次分裂完成开始到下一次分裂结束所经历的全过程,分为间期与分裂期两个阶段。其中,间期分为三期、即DNA合成前期(G1期)、DNA合成期(S期)与DNA合成后期(G2期)。细胞分裂期分为:前期(prophase)、中期(metaphase)、后期(anaphase)、末期(telophase)。在有丝分裂过程中,细胞把遗传物质均等地分配给两个子细胞,这是生物体正常生长、发育和繁殖的基础。 视黄素X受体α(RXRα)属于核受体超家族中的重要成员,从胚胎形成,器官成熟,到生长发育,新陈代谢,RXRα的功能贯穿在整个生命体的生命过程的始终。关于核受体对细胞周期... The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells. Basically, the cell cycle can be divided to the interphase and the cell division. The cell cycle consists of four distinct phases: G1 phase, S phase (synthesis), G2 phase (collectively known as interphase) and M ...