WDR41在乳腺癌中结构和功能的探究
The Structure and Function of WDR41 in Breast Cancer
Abstract
乳腺癌是全世界最常见的几大恶性肿瘤之一，对女性的生命健康构成很大损害。随着对乳腺癌生物学行为异质性探究的不断深入，制订出乳腺癌(尤其是三阴性乳腺癌患者)的综合治疗方案对改善患者的治疗及预后有着十分重要的意义。 基于甲基化芯片筛查技术，我们发现WDR41基因与脑白质疏松症(Leukoariaosis，LA)的发展呈现明显的相关性，且呈现高甲基化状态。令人感兴趣的是，WD40-repeat蛋白家族参与调控了许多肿瘤的发生发展。WDR41作为WD40-repeat蛋白家族一员，仅在2016年才有文献报道其参与了神经系统中多巴胺信号通路的转导，同时在介导C9orf72表达异常诱发的细胞自噬过程中也充... Breast cancer is one of the most common malignant tumor in women, which is damage to woman's life. Along with further study about the heterogeneity of biological behavior and molecular classification of clinical trials of breast cancer, individualized treatment of breast cancer (especially Triple Negative Breast Cancer(TNBC)) is of great significance for improving the prognosis of patients. Our p...