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dc.contributor.advisor帅建伟
dc.contributor.author梁耀极
dc.date.accessioned2018-12-05T01:46:19Z
dc.date.available2018-12-05T01:46:19Z
dc.date.issued2017-12-27
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/170337
dc.description.abstract2009以来,随着受体相互作用蛋白3(RIP3)介导细胞坏死信号通路的发现,跟RIP3相关的功能研究逐渐成为细胞生物学领域的研究热点。我们最近的研究发现RIP3能够显著促进I型干扰素的分泌,特别是促进双链DNA(dsDNA)诱导的I型干扰素的分泌。然而,RIP3是否参与调控DNA病毒诱导的I型干扰素的产生,并且RIP3是如何促进I型干扰素的分泌的,目前还不清楚。本项目拟通过利用CRISPR-Cas9介导的基因敲除技术构建RIP3敲除的细胞系,探讨RIP3在dsDNA和DNA病毒诱导的I型干扰素产生中的作用。我们还将进一步利用免疫沉淀(IP)和质谱联用的方法寻找RIP3的靶向分子,确定RIP3促...
dc.description.abstractReceptor-interacting protein 3 has been reported to be a critical molecular in necroptosis, a form of programmed necrosis, in 2009. From then on, RIP3-related research has became a hot spot in cell biology area. In our recent study, we found that RIP3 plays a critical role in promoting type I interferons (IFNs) production, especially in double-standed DNA (dsDNA) induced IFNs production. However, ...
dc.language.isozh_CN
dc.relation.urihttps://catalog.xmu.edu.cn/opac/openlink.php?strText=58423&doctype=ALL&strSearchType=callno
dc.source.urihttps://etd.xmu.edu.cn/detail.asp?serial=59421
dc.subject受体相互作用蛋白3(RIP3)
dc.subjectI型干扰素
dc.subject双链DNA
dc.subjectDNA病毒
dc.subject分子机制
dc.subjectReceptor-interacting protein 3 (RIP3)
dc.subjecttype I interferons
dc.subjectdsDNA
dc.subjectDNA virus
dc.subjectmolecular mechanism
dc.title受体相互作用蛋白3(RIP3)促进I型干扰素分泌的机制研究
dc.title.alternativeMolecular mechanism of Receptor-Interacting Protein 3 (RIP3) Enhancing Type I Interferons Production
dc.typethesis
dc.date.replied2016-12-15
dc.description.note学位:理学博士
dc.description.note院系专业:物理科学与技术学院_生物化学与分子生物学
dc.description.note学号:2014170007


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