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dc.contributor.advisor邓贤明
dc.contributor.advisor徐庆妍
dc.contributor.author黄桂红
dc.date.accessioned2018-12-05T01:37:52Z
dc.date.available2018-12-05T01:37:52Z
dc.date.issued2018-04-09
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/170026
dc.description.abstract特殊生境来源的真菌生存环境特殊,在适应环境的过程中形成了独特的代谢和防御系统,其次级代谢产物明显有别于普通环境下的真菌,所以特殊生境的真菌成为挖掘新次级代谢产物的新目标。其中,植物内生真菌和海洋真菌就是这类特殊生境真菌资源的重要组成部分。从植物内生真菌和海洋真菌资源中获取药物先导化合物已成为生物学、化学和药学等领域关注的焦点。真菌的许多基因在实验室培养条件下处于沉默状态。近年研究表明通过化学表观遗传操作即利用小分子化学物质抑制真菌中影响表观遗传的酶类,能激活沉默的生物合成基因,诱导真菌产生新的次级代谢产物。本论文选择特殊生境菌株作为研究对象,并且运用化学表观遗传操作,以期获得更多结构新颖且具有...
dc.description.abstractFungus living in a special habitat, such as endophyte fungus and marine fungus, evolves a unique metabolism and defense system in the process of adapting to the environment. These fungi have been considered as rich sources of novel and bioactive secondary metabolites. Recent study show that chemical epigenetic modification of the fungus by reagents such as histone deacetylase (HDAC) inhibitors and...
dc.language.isozh_CN
dc.relation.urihttps://catalog.xmu.edu.cn/opac/openlink.php?strText=59832&doctype=ALL&strSearchType=callno
dc.source.urihttps://etd.xmu.edu.cn/detail.asp?serial=61539
dc.subject植物内生真菌
dc.subject海洋真菌
dc.subject次级代谢产物
dc.subject化学表观遗传操作
dc.subjectendophytic fungi
dc.subjectmarine fungi
dc.subjectsecondary metabolite
dc.subjectepigenetic manipulation
dc.title植物内生真菌次级代谢产物的研究及化学表观遗传学的应用初探
dc.title.alternativeStudies on the Secondary Metabolites of Endophytic Fungi and preliminary application of chemical epigenetics
dc.typethesis
dc.date.replied2017-05-18
dc.description.note学位:理学硕士
dc.description.note院系专业:生命科学学院_微生物学
dc.description.note学号:21620141152442


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