NMI负调控NF-κB/p65功能的研究

Abstract

NF-κB是细胞内重要的转录因子之一，其调控细胞内大量基因的表达，这些基因参与机体重要的生理过程，如细胞存活和增殖、细胞凋亡、细胞应激应答、炎症反应和免疫应答。许多刺激都可以活化NF-κB信号通路，大部分刺激引起NF-κB的活化均汇集到IKK复合体。IKK复合体磷酸化IκBα，导致IκBα被泛素化并最终通过26S蛋白酶体降解。IκBα的降解会导致NF-κB二聚体的释放，自由的NF-κB二聚体进入细胞核，在细胞核中经过一系列翻译后修饰，NF-κB二聚体会结合到相应靶基因的启动子或增强子的κB位点从而发挥转录调控作用。由于NF-κB调控的基因参与众多生理活动，NF-κB调控发生紊乱将导致多种疾病，...

NF-κB is an important cellular transcription factor. NF-κB regulates diverse genes expression which is involved in many physiological processes such as cell survival and proliferation, apoptosis, cellular stress response, inflammation and immune response. Many stimuli activate NF-κB, and most of these diverse stimuli converge on the IκB kinases (IKK) complexes. Activated IKK phosphorylates IκBα. T...