白介素11（IL11）在肿瘤中的作用研究
Study on the role of Interleukin (IL11) in tumor
Abstract
IL11（Interleukin11）是IL6细胞因子家族的一员，是一种多功能的细胞因子，最初在临床上用于治疗化疗引起的血小板减少症。IL11与其受体结合后可以启动三条信号通路：JAK-STAT3信号通路、RAS-RAF-ERK信号通路和PI3K-AKT-mTORC1信号通路，进一步促进肿瘤细胞的生存、增殖、分化、迁移、侵袭以及血管生成能力。IL11在多种肿瘤样本中都存在高表达现象，在本研究中，我们建立了IL11过表达结直肠癌细胞系CT26和肝癌细胞系Hep1-6，发现过表达IL11对CT26和Hep1-6细胞的增殖能力没有显著的影响，但是可以促进细胞的克隆形成能力，IL11的过表达也能够促进... IL11 is a member of the IL6 family cytokines that is defined by the shared use of the GP130 signal transducing receptor subunit. It is a multifunctional cytokine and firstly used for promoting maturation of platelet. IL11 binds to its transmembrane co-receptor result in three signaling pathways: JAK-STAT3 signaling pathway, PI3K-AKT signaling pathway and RAS-RAF-ERK signaling pathway. These pathwa...