人类免疫缺陷病毒1型糖蛋白gp41近膜端的免疫和中和表位研究
Study on Immunization and Neutralization of Epitope Membrane- Proximal External Region Epitope of Human Immunodeficiency Virus Type 1 Glycoprotein gp41
Abstract
HIV自发现以来,已经累计造成约4000万人死亡,并且到2015年为止大约有3670万人携带HIV病毒。HIV是一种逆转录病毒,能够攻击人类的免疫系统,可以潜伏在病人体内数多年而不发病,并且可以通过多种方式逃避机体的免疫系统的攻击。到目前还没有有效的疫苗来控制HIV的感染和蔓延,因此,对于HIV疫苗的研究和探索有很大的意义。 因为HIVgp41糖蛋白的近末端区(MPER)是线性表位,高度保守而且富含酪氨酸,并且是广谱中和抗体2F5,4E10,10E8等识别的位点,因此本研究选择MPER表位作为研究对象。本研究利用白喉毒素A亚基(CRM197-A)作为蛋白载体,融合表达MPER的2F5(ELL... The HIV has resulted in 40 million death since it has been found in 1981 and there are 36.7 billion people living with it. HIV is a retrovirus that can attack the human immune system and can lurk in the patient for decades without disease, and can escape the immune system's attacks in a variety of ways. There is no effective vaccine to control the infection and spread of HIV, therefore, for the HI...