Gasdermin D的N端片段在细胞焦亡时寡聚并迁移上细胞质膜
The N terminal fragement of Gasdermin D could forms oligomers and migrates to the plasma membrane in pyroptosis
Date
2018-04-09Collections
- 生命科学－学位论文 [2445]
Abstract
炎症小体是一个由多种蛋白形成的功能性复合物，在固有免疫中有重要作用。在细胞炎症反应中，炎症小体可以激活caspase1的活性，进而剪切GSDMD诱发细胞焦亡，同时还能介导细胞因子IL-1β和IL-18的剪切成熟和分泌。细胞焦亡的失调和炎症小体的异常激活都会导致多种自身免疫病。细胞焦亡是新划分的一种程序性细胞死亡方式，最近GSDMD蛋白的发现是细胞焦亡研究的巨大进展之一。GSDMD蛋白在被caspase1/caspase11剪切后，会执行细胞焦亡。但是GSDMD执行细胞焦亡的具体功能机制还未有报道。本文中，我们通过体内体外实验验证了GSDMD蛋白的作用机制。研究结果显示，GSDMD-N端片段在细... Inflammasome is a functional protein complexes, which plays an important role in innate immunity. Inflammation can activate the activity of caspase1, then cut GSDMD and IL-1βand IL-18, which can induced pyroptosis and cytokine secretion respectively. They both have a hand in innate immunity, the disorders of pyroptosis and the abnormal activation of inflammasome will lead to a variety of autoimmun...