调控谷氨酸转运体对帕金森病模型小鼠神经保护效应及机制的研究
Neuropreotective effects and mechanism of regulating glutamate transporters in the mice model of Parkinson's disease
Date
2018-04-12Collections
- 生命科学－学位论文 [3249]
Abstract
帕金森病（Parkinson’sdisease，PD）是一种中老年常见的神经系统变性疾病，兴奋性毒性作用是PD发病的关键机制，谷氨酸转运体通过摄取谷氨酸减轻兴奋性毒性效应。研究表明，通过上调谷氨酸转运体的表达，可以减弱兴奋性毒性对神经系统的损伤，从而保护多巴胺神经元，改善PD模型小鼠的运动行为障碍。因此，本课题主要研究谷氨酸转运体在PD发病中的调控策略，探讨通过提高谷氨酸转运体来治疗PD的可能性，分为两部分简述如下。 一、雷帕霉素在PD模型小鼠中上调谷氨酸转运体和IL-6的表达MPTP小鼠模型是一种公认的PD小鼠模型，雷帕霉素可以小鼠保护多巴胺神经元免受MPTP的损伤，我们的研究证明雷帕霉素... Abstract Parkinson's disease (PD) is a common neurodegenerative disease, which is mainly appeared in the middle aged and elderly people, and glutamate excitotoxicity contributes significantly to the pathogenesis of PD. Glutamate transporter attenuates glutamate excitotoxicity via glutamate uptake. Studies have shown that upregulation of glutamate transporters could weaken excitotoxic damage to th...