初步探究Adp抑制脂肪细胞分化的分子机制

Abstract

近年来，随着世界人口肥胖率的上升，肥胖已经开始取代营养不良和传染性疾病，成为全球影响健康的最重要因素。能量摄入与消耗的失衡会导致肥胖，肥胖的发生又会增加糖尿病、心血管疾病和癌症的发病率，对人类健康造成了极大的威胁。 Adipose(Adp)是一个在进化上很保守且具有剂量效应的抗肥胖作用的基因。经研究证实，Adp可抑制线虫、果蝇、小鼠的脂肪积累，在3T3-L1前脂肪细胞中，过表达Adp可抑制脂肪细胞的分化；降低Adp的表达，则可促进脂肪细胞的分化。 有研究报导：DDB1-CUL4泛素化系统的底物受体有30多种，有18种是DCAFs，DCAFs中的14种含有WD40重复结构域，Adp便是其中之...

In recent years, with the increasingly obesity rate around the world, the obesity which is induced by an imbalance between energy intake and consumption begins to surpass undernutrition and infectious diseases as the most significant threat to health. Furthemore, the obesity may even increase the incidence of diabetes, cardiovascular disease, and cancer, bringing a great threat to human health. A...