醛糖还原酶通过调控IRS-1和LKB1-AMPKa信号转导促进胰岛素抗性、肥胖与NAFLD的发生发展

Abstract

多元醇糖代谢支路（thepolyolpathway,PP）是糖酵解-三羧酸循环以及戊糖磷酸循环之外细胞葡萄糖代谢的第三个最重要的途径。醛糖还原酶（aldosereductase,AR）是PP的第一个和限速酶，它负责将葡萄糖还原为山梨醇，后者在山梨醇脱氢酶（sorbitoldehydrogenase,SDH）的作用下生成果糖。AR/PP在细胞代谢、炎症反应、免疫应答等生命活动中扮演重要角色，AR/PP的异常调控与糖尿病和糖尿病并发症的发生发展紧密相关。同时，AR/PP的过度激活产生的果糖与肝脂肪化或非酒精性脂肪肝（NAFLD）有着紧密的联系。另一方面，果糖代谢不受肝能量水平（AMP/ATP）的调...

The polyol pathway (PP) is the third most important pathway of glucose metabolism besides the glycolysis - tricarboxylic acid cycle and the pentose phosphate pathway. Aldose reductase (AR) is the first and rate-limited enzyme of PP, it catalyzes glucose reduction to sorbitol, and the latter generates fructose with the aid of sorbitol dehydrogenase (SDH). AR/PP plays an important role in cell metab...