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dc.contributor.advisor俞春东
dc.contributor.author任文静
dc.date.accessioned2018-12-05T01:37:30Z
dc.date.available2018-12-05T01:37:30Z
dc.date.issued2018-04-09
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/169873
dc.description.abstractSRC-1(Steroidreceptorcoactivator1)是类固醇激素受体辅激活因子SRC家族中的一员,它不仅辅激活雌激素受体(androgenreceptor,AR)和雄激素受体(estrogenreceptor,ER)等激素受体,而且还能辅激活其他转录因子,如β-catenin,NF-κB,HNF4,HIF1,E2F1和p53等。SRC-1在乳腺癌和前列腺癌的发生发展中起着重要的作用,但是对于它在结直肠癌发生发展中的作用仍不清楚。 本研究中,我们发现SRC-1在结直肠癌组织和细胞系中高表达。因此,推测SRC-1在结直肠癌的发生发展过程中发挥一定作用。实验结果表明,在结直肠癌细胞...
dc.description.abstractSteroid receptor coactivator 1 (SRC-1) is a member of Steroid receptor coactivator family. SRC-1 not only interacts with steroid receptors such as androgen receptor (AR) and estrogen receptor (ER), but also coactivates many other transcription factors, such as β-catenin, NF-κB, HNF4, HIF1, E2F1 and p53. SRC-1 has been shown to play an important role in the progression of breast and prostate cancer...
dc.language.isozh_CN
dc.relation.urihttps://catalog.xmu.edu.cn/opac/openlink.php?strText=59942&doctype=ALL&strSearchType=callno
dc.source.urihttps://etd.xmu.edu.cn/detail.asp?serial=61786
dc.subjectSRC-1
dc.subject结直肠癌
dc.subjectHedgehog信号通路
dc.subjectSteroid receptor coactivator 1 (SRC-1)
dc.subjectcolorectal cancer (CRC)
dc.subjectHedgehog Signaling
dc.titleSRC-1通过Hedgehog信号通路促进结直肠癌细胞增殖、迁移和侵袭的作用研究
dc.title.alternativeSRC-1 Promotes Colorectal Cancer Cell proliferation, Migration and Invasion via Hedgehog Signaling pathway
dc.typethesis
dc.date.replied2017-05-17
dc.description.note学位:理学硕士
dc.description.note院系专业:生命科学学院_生物化学与分子生物学
dc.description.note学号:21620141152559


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