Optimization of beta - Cyclodextrin Inclusion Technology of Volatile Oil from Pueraria Compound by Orthogonal Design
- 医学院－已发表论文 
目的优选葛根复方挥发油的包合工艺,提高制剂的稳定性。方法采用饱和水溶液法制备包合物,以挥发油中藁本内酯、桂皮醛、甲基丁香酚包合率及包合物得率为综; 合评价指标,采用正交试验法考察挥发油与beta; -环糊精的比例、包合时间、包合温度对包合工艺的影响,优化得到葛根复方中挥发油的最优包合工艺。结果葛根复方中挥发油的最佳包合工艺条件为挥发油与be; ta -环糊精比例为1:8,包合温度为30℃,包合时间为1h,验证试验中,藁本内酯、桂皮醛及甲基丁香酚的包合率为别为86.58% ; 0.009%,73.34% 0.001%,68.89% 0.020%,包合物得率为67.98% ; 0.047%。结论所确定的包合工艺挥发油的包合率高、工艺稳定可行。Objective To obtain the optimized technology of volatile oil from; Pueraria Compound with beta - Cyclodextrin (beta - CD). Methods The; inclusion compound was prepared by saturated peroxide solution method.; In order to optimize inclusion technology,orthogonal design was; performed,with the content of multi - target ingredient,such as; ligustilide,cinnamic aldehyde, methyleugenol and the yield of inclusion; as comprehensive evaluation indexes. Three factor was performed,the; ratio of volatile oil (mL) to beta - CD (g),the inclusion temperature; and the inclusion time. Results The optimum conditions for inclusion; process were as follow:the ratio of volatile oil (mL) to beta - CD (g); was 1:8,the inclusion temperature was 30℃ and the inclusion time was 1h.; With the optimum inclusion condition,the content of ligustilide,cinnamic; aldehyde and methyleugenol and the yield of inclusion were 86.58% ; 0.009%,73.34% 0.001%,68.89% 0.020%,and 67.98% 0.047%,respectively.; Conclusion The optimum inclusion condition was stable and reproducible; with a high inclusion yield.