• 中文
    • English
  • English 
    • 中文
    • English
  • Login
View Item 
  •   DSpace Home
  • 医学院
  • 医学院-已发表论文
  • View Item
  •   DSpace Home
  • 医学院
  • 医学院-已发表论文
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

黄连素对多囊卵巢综合征大鼠高雄激素状态及StAR蛋白表达的影响
Influence of berberine on hyperandrogenism of rats with polycystic ovarian syndrome and StAR protein expression

Thumbnail
Full Text
黄连素对多囊卵巢综合征大鼠高雄激素状态及StAR蛋白....pdf (4.745Mb)
Date
2017
Author
郑慧颖
李庆端
蔡雪红
叶南方
贺颖
Collections
  • 医学院-已发表论文 [2567]
Show full item record
Abstract
目的:研究黄连素对多囊卵巢综合征(PCOS)大鼠治疗作用及机制。方法:将48只6周龄SPF级雌性SD大鼠随机分为空白对照组和造模组,造模组采用来; 曲唑(1mg·kg~(-1)·d~(-1))灌胃诱导PCOS模型。造模结束后,将造模成功的大鼠随机分为模型对照组、二甲双胍组、黄连素组,每组11; 只。治疗期间空白对照组、模型对照组均用1%羧甲基纤维素灌胃,二甲双胍组用1%羧甲基纤维素+二甲双胍(135mg·kg~(-1)·d~(-1))灌; 胃,黄连素组用1%羧甲基纤维素+黄连素(81mg·kg~(-1)·d~(-1))灌胃。测定大鼠血清睾酮、空腹胰岛素,光镜下观察大鼠卵巢HE染色病; 理片和StAR免疫组化病理片。结果:本实验模型大鼠出现典型的PCOS表现:卵巢呈多囊样改变;血清睾酮升高(P<0.05);空腹胰岛素升高(P<0; .01),提示存在胰岛素抵抗。二甲双胍和黄连素均能改善模型大鼠的胰岛素抵抗,但黄连素降低睾酮的能力优于二甲双胍(P<0.05)。卵泡膜细胞的细胞; 膜上StAR密度随睾酮值升高而升高。结论:黄连素有治疗PCOS的作用,它不仅能改善胰岛素抵抗,还能通过降低卵泡膜细胞的细胞膜上StAR密度降低血; 清睾酮值,治疗高雄激素血症。
 
Objective: To study the therapeutic effect and mechanism of berberine on; rats with polycystic ovarian syndrome. Methods: Forty-eight six-week SPF; female SD rats were randomly divided into blank control group and model; group. The model group received letrozole to induce PCOS model, then the; successful modeling rats undergone were divided into model control; group, melbine group and berberine group. During the treatment, 1%; carboxymethylcellulose was used on the blank control group and model; control group, 1% carboxymethylcellulose plus melbine were used on the; melbine group while 1% carboxymethylcellulose plus berberine were used; on the berberine group. The testosterone and fasting insulin of rats; were detected, the ovarian pathological slices of HE staining and the; StAR immunohistochemical pathological slices of rats were observed under; light microscopes. Results: In this experiment, the model rats have; typical PCOS manifestations: the ovary has polycystic changes; the; testosterone rises (P<0.05); the fasting insulin rises (P<0.01), which; indicate that insulin resistance exists. Both melbine and berberine can; improve the insulin resistance of model rats, but the performance of; berberine in lowering androgen is better than melbine. The testosterone; of PCOS hyperandrogenism is positively related to the StAR density on; the cytomembrane of theca cells. Conclusion: Berberine has effect on; PCOS. It can not only improve insulin resistance but also treat; hyperandrogenism by lowering the StAR density on the cytomembrane of; theca cells to decrease the testosterone.
 
Citation
中华中医药杂志,2017,(9):4230-4234
URI
https://dspace.xmu.edu.cn/handle/2288/166219

copyright © 2002-2016  Duraspace  Theme by @mire  厦门大学图书馆  
About | Policies
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

copyright © 2002-2016  Duraspace  Theme by @mire  厦门大学图书馆  
About | Policies