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dc.contributor.author王柏桦
dc.contributor.author唐忠辉
dc.contributor.author孟加榕
dc.contributor.author温路生
dc.contributor.author黄仲庆
dc.contributor.author潘羡心
dc.date.accessioned2018-11-26T08:58:47Z
dc.date.available2018-11-26T08:58:47Z
dc.date.issued2017
dc.identifier.citation包头医学院学报,2017,(7)
dc.identifier.issn1006-740X
dc.identifier.other10.16833/j.cnki.jbmc.2017.07.003
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/166168
dc.description.abstract目的:了解漳州地区人乳头瘤病毒(human papilomavirus,HPV)基因型与宫颈病变的关系.方法:应用基因芯片技术对200例宫颈病变患者石蜡组织标本进行24种HPV基因型检测,以组织病理学诊断作为宫颈病变确诊的金标准.结果:(1)200例标本中,HPV阳性率为51.50 %;检出20种基因型,常见基因型依次是HPV16(27.97 %)、HPV18(8.39 %)、HPV58(8.39 %)、HPV59(7.69 %)、HPV54(7.69 %);其中低危型HPV占16.08 %,以HPV54、HPV6和HPV70多见;高危型HPV为83.92 %,以HPV16、HPV18、HPV58和HPV59多见;HPV单一感染率与多重感染率分别为67.96 %和32.04 %,以合并HPV16的多重感染为最常见,占42.42 %.(2)HPV感染率随着年龄增加而增加,以年龄≥60岁年龄段阳性率(66.67 %)最高,但各年龄段HPV感染率差异无统计学意义(P>0.05).(3)不同类型HPV基因型可引起不同程度宫颈病变,慢性宫颈炎、低级别宫颈上皮内瘤变(L-CIN)、高级别宫颈上皮内瘤变(H-CIN)和宫颈鳞癌,常见基因型分别依次是HPV54、HPV16/HPV51/HPV58;HPV59、HPV53/HPV58;HPV16、HPV58/HPV59;HPV16、HPV18、HPV51/HPV54,而HPV16、HPV18与宫颈病变相关(P<0.05).(4)HPV感染率随着宫颈病变进展而增加(P<0.05);不同宫颈病变中多重感染率低于单一感染率(P<0.05);多重感染、低危型多重感染、高危型感染、高危型多重感染、高低混合型多重感染的各组感染率在不同级别宫颈病变差异有统计学意义(P<0.05).结论:随着宫颈病变进展HPV感染率呈升高的趋势,持续高危型感染和多重感染是加重宫颈病变的重要因素,HPV16、HPV18基因型感染不但多见而且使宫颈癌的患病风险增加.
dc.description.abstractObjective:To investigate the relationship between human papilomavirus (HP) genotypes and cervical lesions in Zhangzhou district. Method: The gene chip technology was adopted to test 24 types of HPV genotypes in paraffin tissue from :200 cases of patients with cervical lesions, and histopathological diagnosis was used as gold standard for cervical lesions confirmation. Results: (1)In the 200 specimens, the positive rate of HPV was 51.50% (103/200), 20 genotypes were detected, and the common types were HPV16 (27.97 % ), HPV18 (8.39 % ), HPV58 (8.39 % ), HPV59 (7.69 % ) and HPV54 (7.69 % ). In the HPV posi- tive cases, the rates of low - risk type of HPV were 16.08%, and the common types were HPV54, HPV 6 and HPV70; the rates of high - risk type of HPV were 83. 92 %, and the common types were HPV16, HPV18, HPV58 and HPV59 ; the rates of simple infection and multiple infection were 67.96 % and 32.04 % respective ly, and HPV 16 merged multiple infection was the most common, accounting for 42.42 %. (2) The infection rate of HPV increased with the increase of age, the posi- tive rate in above 60 years group was the highest (66.67 % ), but there were no significant differences among different age groups ( P 〉 0.05 ). (~ HPV of different genotype could induce different cervical lesions, such as chronic cervicitis, low - CIN, high - CIN, squamous cell carcinoma, and the common types were HPV54, HPVI6 / HPV51 / HPV58, HPV59, HPV53 / HPV58, HPV16, I-IPV58 / HPV59, HPV16, HPV18, HPV51 / HPV54. HPVI6 and HPVI8 were closely correla- ted with the cervical lesions ( P 〈 0.05 ). The infection rate of HPV increased with the progression of cervical lesions ( P 〈 0.05 ) ; The rates of multiple HPV in- fection were significantly lower than that of single HPV infection in different cervical lesions ( P 〈0.05 ) ; There were statistical dift~rences in the rates of the multiple r infection, low - risk multiple infection, high - risk infection, high - risk
dc.description.sponsorship漳州市自然科学基金科技项目(ZZ2012J21)
dc.language.isozh_CN
dc.subject人乳头瘤病毒
dc.subject基因型
dc.subject宫颈病变
dc.subjectCervical lesions
dc.title漳州地区宫颈病变患者HPV基因型分布特点
dc.title.alternativeDistribution of HPV genotypes of cervical lesions patients in Zhangzhou district
dc.typeArticle


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