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dc.contributor.author余越
dc.contributor.author陶春
dc.contributor.author杨海跃
dc.contributor.author王天宇
dc.contributor.author薛丹萍
dc.contributor.author田雪梅
dc.contributor.author张美敬
dc.contributor.author房盛楠
dc.contributor.author宋洪涛
dc.date.accessioned2018-11-26T08:57:44Z
dc.date.available2018-11-26T08:57:44Z
dc.date.issued2017
dc.identifier.citation药学学报,2017,(6):985-991
dc.identifier.issn0513-4870
dc.identifier.other10.16438/j.0513-4870.2016-1198
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/165993
dc.description.abstract研究制备了不同孔径的介孔二氧化硅纳米粒及西罗莫司自微乳。使用扫描电镜、透射电镜、小角度X-射线衍射、氮气吸附-脱附表征制得的介孔二氧化硅纳米粒,发现其为有序的纳米孔道结构,孔径分别为6.3、8.1和10.8 nm,通过粒径测定仪测得西罗莫司自微乳粒径为20.6±1.3 nm。通过搅拌法制备载西罗莫司自微乳介孔二氧化硅纳米粒。研究发现,当西罗莫司自微乳与介孔二氧化硅纳米粒质量比2∶1时为最佳比例,载药量约为0.83%,且固体粉末流动性良好。采用差示扫描量热法表明,西罗莫司以非晶体或无定形存在于载体材料中,重分散性良好。孔径大小对于载西罗莫司自微乳介孔二氧化硅纳米粒在250 m L水中2 h的释放终点并没有显著影响,但对于最初40 min释放结果影响较大。综上,介孔二氧化硅纳米粒有望成为一种新型的自微乳吸附剂。
dc.description.abstractThe mesoporous silica nanoparticles (MSN) in different pore size and sirolimus (SRL) loaded self-microemulsifying drug delivery system (SMEDDS) were prepared. The results in morphology were collected by scanning electron microscope, transmission electron microscope, small-angle X-ray diffraction, and N2 adsorption-desorption. The results showed that the prepared MSN has ordered nanochannels with a pore size of 6.3, 8.1, 10.8 nm, respectively. The particle size of SRL-SMEDDS were measured by particle sizing system, which was 20.6 ± 1.3 nm. The stirring method was developed to prepare SRL-SMEDDS-MSN. It was found that the optimal ratio of SRL-SMEDDS to MSN was 2: 1, while the drug loading rate was near 0.83%, and the flow properties of SRL-SMEDDS-MSN were of good condition. The differential scanning calorimetry results proving a molecular or amorphous dispersed state of SRL in MSN while the suspension experiment has shown great reconstitution properties of SRL-SMEDDS-MSN. There is no significant influence on maximum drug release rate of different pore size of SRL-SMEDDS-MSN in 250 mL water within 2 h, while the results of the first 40 min have an obvious difference. Above all, MSN might provide a new strategy for the solidification of SMEDDS.
dc.description.sponsorship福建省科技计划重点资助项目(2013Y0074)
dc.language.isozh_CN
dc.subjectIn vitro dissolution rate
dc.subjectMesoporous silica nanoparticle
dc.subjectNano-carrier
dc.subjectSelf-microemulsifying drug delivery system
dc.subjectSirolimus
dc.subjectSolidification
dc.subjectin vitro dissolution rate
dc.title不同孔径介孔二氧化硅纳米粒的制备及其用于固化西罗莫司自微乳
dc.title.alternativePreparation of mesoporous silica nanoparticles in different pore size and its use in the solidification of sirolimus loaded self-microemulsifying drug delivery system
dc.typeArticle


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