Effect of Recombinant Human Erythropoietin on Anemia and Sleep in Malignant Tumor Patients
- 药学院－已发表论文 
目的：探讨重组人红细胞生成素（EPO）对恶性肿瘤患者贫血及睡眠的影响。方法：将2014年5月至2017年1月我院收取的68例恶性肿瘤相关性贫血患者随机分为研究组和对照组,每组34例,对照组在化疗的同时加用力蜚能,研究组在对照组基础上应用重组人EPO,连续治疗4周。治疗前后检测2组血红蛋白（Hb）、红细胞计数（RBC）、红细胞压积（HCT）等指标变化,采用匹兹堡睡眠质量指数量表（PSQI）评估患者睡眠质量,观察2组不良反应。结果：治疗后2组Hb及研究组RBC和HCT均较治疗前升高,且研究组高于对照组（P〈0.05或P〈0.01）。治疗前研究组和对照组PSQI评分分别为（7.58±2.32）分、（7.49±2.15）分,治疗后分别为（4.12±1.23）分、（7.33±2.16）分,研究组PSQI评分较治疗前降低,且低于对照组（P〈0.01）。2组治疗期间均无明显不良反应发生。结论：重组人EPO可明显改善恶性肿瘤患者贫血状态,提高患者睡眠质量,且安全性高。Objective： To investigate the effect of recombinant human erythropoietin（ EPO） on anemia and sleep in patients with malignant tumor. Methods： 68 patients with malignant tumor-related anemia admitted to our hospital from May. 2014 to Jan. 2017 were randomly divided into study group and control group,34 cases in each group,the control group was given Lifeineng at the same time of the chemotherapy,the study group based on the control group was given the application of recombinant human EPO,the 2 groups had continuous treatment for 4 weeks. The changes of hemoglobin（ Hb）,red cell count（ RBC）,red blood cell pressure product（ HCT） in the 2 groups before and after treatment were measured. Pittsburgh Sleep Quality Index（ PSQI） was used to evaluate the quality of sleep and the adverse reactions of the 2 groups were observed. Results： After treatment,the Hb of the 2 groups and RBC and HCT of the study group were higher than those before treatment,and the study group were higher than those of the control group（ P〈 0. 05 or P〈 0. 01）. Before treatment,the PSQI scores of the study group and the control group were（ 7. 58 ± 2. 32） points and（ 7. 49 ± 2. 15） points respectively,after treatment,they were（ 4. 12 ± 1. 23） points and（ 7. 33 ± 2. 16） points respectively. The PSQI score of the study group decreased than before treatment,and which was lower than the control group（ P〈 0. 01）. There was no significant adverse reactions occurred in the 2 groups during the treatment. Conclusion： Recombinant human EPO can significantly improve the anemia in patients with malignant tumors,improve the quality of sleep in patients with high safety.