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dc.contributor.author柯金珍
dc.contributor.author颜志文
dc.contributor.author陈丰庆
dc.contributor.author罗琪
dc.date.accessioned2018-11-26T08:57:33Z
dc.date.available2018-11-26T08:57:33Z
dc.date.issued2017
dc.identifier.citation中国临床药学杂志,2017,(4)
dc.identifier.issn1007-4406
dc.identifier.other10.19577/j.cnki.issn10074406.2017.04.009
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/165898
dc.description.abstract目的观察丁丙诺啡透皮贴剂治疗中重度慢性疼痛的疗效和安全性。方法收集2015年10月至2016年3月在我院骨科门诊确诊为中重度慢性疼痛患者68例,给予丁丙诺啡透皮贴剂进行止痛治疗,初始剂量5 mg,qw,根据疼痛情况调整剂量至无痛或基本无痛状态。对每位患者随访1个月,分别评估患者治疗前后疼痛强度、镇痛效果、生活质量、用药依从性,同时监测药物不良反应。结果治疗前、后患者疼痛数字评分分别为(5.90±1.05)分和(1.35±0.75)分,P〈0.05;疼痛总缓解率为91.18%;治疗后SF-36生活质量量表(中文版)8个方面维度分数和用药依从性均较治疗前显著提高(P〈0.05);药物不良反应发生率为8.82%。结论丁丙诺啡透皮贴剂具有镇痛稳定、作用持久、不良反应轻、用药依从性高等特点,可倡导应用于中重度慢性疼痛的治疗。
dc.description.abstractAIM To observe the efficacy and safety of buprenorphine transdermal patches in relieving moderate to severe chronic pain. METHODS From October 2015 to March 2016,a total of 68 patients with moderate to severe chronic pain in orthopaedics clinic in our hospital were treated with buprenorphine transdermal patches,used with an initial dose of 5 mg qw and adjusted dose until pain disappeared. After one-month follow-up,the patients with moderate to severe chronic pain were respectively evaluated and pain relief,quality of life,medication compliance and adverse drug reactions were compared. RESULTS At pre-therapy and post-treatment,the scores of NRS( numerical rating scale) of the patients were( 5. 90 ± 1. 05) and( 1. 35 ± 0. 75) respectively,P 〈0. 05.There was significant difference befor and after treatment in pain relief,life quality and medication compliance( P 〈0. 05). The total remission rate in pain was 91. 18%. It was 8. 82% in incidence rate of adverse drug reactions. CONCLUSION Buprenorphine transdermal patches have the characteristics of stable analgesia,long duration of effect,less adverse drug reactions and higher compliance,and can be advocated for in the treatment of moderate to severe chronic pain.
dc.language.isozh_CN
dc.subject丁丙诺啡
dc.subject透皮贴剂
dc.subject中重度慢性疼痛
dc.subject临床疗效
dc.subject安全性
dc.title丁丙诺啡透皮贴剂治疗中重度慢性疼痛的疗效及安全性
dc.title.alternativeEfficacy and safety of buprenorphine transdermal patches in relieving moderate to severe chronic pain
dc.typeArticle


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