中药扶阳清毒法对乳腺癌新辅助化疗患者细胞免疫功能的影响

Abstract

目的研究与分析中药扶阳清毒治疗对乳腺癌新辅助化疗患者细胞免疫功能的具体影响。方法方便选取该院自2014年3月—2017年3月收治的乳腺癌初治患者68例,按照随机数字表法将其随机分为单一治疗组与联合治疗组,每组34例,予以单一治疗组患者单纯新辅助化疗治疗,予以联合治疗组患者新辅助化疗联合中药扶阳清毒法治疗,另选取该院同一时期收治的乳腺纤维瘤患者34例患者做为对照组,对单一治疗组及联合治疗组两组患者治疗前后细胞免疫功能变化进行观察与对比。结果单一治疗组患者与联合治疗患者组两组治疗前的CD3、CD4、CD8及NK细胞数量与对照组患者相比差异有统计学意义（P〈0.05）;治疗后,单一治疗组患者CD3、CD4、CD8及NK细胞数量分别为（46.62±8.67）、（34.16±6.68）、（29.32±6.41）、（31.05±5.35）,与治疗前相比差异有统计学意义（P〈0.05）;治疗后,联合治疗组患者CD3、CD4、CD8、CD4/CD8值及NK细胞数量分别为（49.18±8.87）、（36.51±6.65）、（27.54±7.50）、（1.31±0.65）、（32.53±5.44）,与治疗前相比具有一定变化,但对比结果差异无统计学意义（P〉0.05）。结论对于接受新辅助化疗出现细胞免疫功能下降患者行中药扶阳清毒法联合治疗可明显改善其细胞免疫功能,中药扶阳清毒治疗可对乳腺癌患者细胞免疫功能的改善起到积极作用。

Objective This paper tries to study and analyze the specific effects of Chinese medicine ＂Fuyang detoxification＂on cellular immune function in breast cancer patients undergoing neoadjuvant chemotherapy. Methods 68 patients with breast cancer in this hospital from March 2014 to March 2017 were selected and randomly divided into the single treatment group and the combined treatment group, with 34 patients in each group, the patients in the treatment group adopted single Danchunxin adjuvant chemotherapy treatment, the combined group was treated with neoadjuvant chemotherapy detoxification combined with traditional Chinese medicine Fuyangqing, another 34 mammary fibroma patients in this hospital during the same period were selected as the control group. The changes of cellular immune function were observed and compared before and after a single treatment group and combined treatment between the two groups. Results CD3, CD4, CD8 and NK cells in the treatment group and combined treatment group before treatment were（46.62 ±8.67）,（34.16 ±6.68）、（29.32 ±6.41）,（31.05±5.35）, significant different from those before treatment（P0.05）; after treatment, a single treatment of patients with CD3, CD4, CD8 and the number of NK cells were（49.18±8.87）,（36.51±6.65）,（27.54±7.50）,（1.31±0.65）,（32.53±5.44）, but the result was not statistically significant（P〉0.05）. Conclusion Neoadjuvant chemotherapy for the cell immune function decline in patients with traditional Chinese medicine Fuyangqing combined therapy can significantly improve the cellular immune function, Chinese medicine treatment can help Fuyang detoxification on immune cells in patients with breast cancer plays a positive role in improving the function.