Research Progress on the Synthesis and Bioactivities of Indole-3-glyoxylamide Derivatives
- 药学院－已发表论文 
综述了吲哚-3-乙醛酰胺类化合物(ID)的合成及生物活性的研究进展。ID具有抗肿瘤、抗病毒、抗菌、抗炎、腺苷受体功能调节、缓解疼痛和抗类风湿关节; 炎等多种生物活性,在药物化学领域有广泛应用。ID的合成方法主要为:吲哚母核与乙酰氯在乙醚(或THF)中于室温反应1; h制得含草酰氯结构的中间体;中间体与取代胺基化合物和二异丙基胺乙基胺反应合成ID。并对ID未来的应用作了简要展望。The synthesis and bioactivities of indole-3-glyoxylamide derivatives(ID); were reviewed with thirty two references. ID, which exhibited well; bioactivities in antitumor, antivirus, antibacterial, anti-inflammatory,; adenosine regulation, etc, were widely applied in pharmaceutical; chemistry. The main method for synthesizing ID was as follows: the; intermediate containing oxalyl chloride(M) was obtained by the reaction; of indole nuclear parent with acetylchloride in diethyl ether(or THF) by; reaction rt for 1h. ID were synthesized by the reaction of M with; substituted amino compound and N,N-diisopropylethylamine. The forecast; of the application of ID was briefly proposed.