Efficacy of ulinastatin combined with gamma globulin in treating patients with acute purulent peritonitis
- 药学院－已发表论文 
目的观察研究乌司他丁联合丙种球蛋白治疗急性化脓性腹膜炎的疗效分析。方法选取厦门大学附属第一医院杏林分院普外科2013年3月~2015年3月收治的确诊为急性化脓性腹膜炎的患者共70例,按随机数字表法分为观察组和对照组,每组各35例,对照组给予常规保守治疗,观察组给予乌司他丁联合丙种球蛋白治疗,治疗结束后,随访并记录2组患者相关指标的变化等情况。结果观察组患者治疗后内毒素含量为(626.9±130.5)pg/mL,低于对照组(867.4±124.2)pg/mL(P<0.05)。观察组患者治疗后有效率高于对照组(97.14%vs.77.14%;χ~2=7.467,P<0.05)。结论乌司他丁联合丙种球蛋白治疗急性化脓性腹膜炎的临床治疗效果确切,整体治疗效果优于常规治疗。Objective To observe the efficacy of ulinastatin combined with gamma globulin in treating patients with acute purulent peritonitis.Methods 70 cases diagnosed with acute purulent peritonitis from March 2013 to March 2015 were randomly divided into observation group and control group,35 cases in each group. The control group received conventional treatment and observation group received ulinastatin combined with gamma globulin treatment. The related indicators were followed up and recorded in two groups post-treatment. Results The endotoxin content post-treatment in observation group was lower than control group[( 626. 9 ± 130. 5) vs.( 867. 4 ± 124. 2) pg / mL,P < 0. 05]. The effective rate in observation group was higher than control group( 97. 14% vs. 77. 14%; χ~2= 7. 467,P < 0. 05). Conclusion Ulinastatin combined with gamma globulin has the exact efficacy in treating patients with acute purulent peritonitis whose efficacy is better than conventional treatment.