Efficacy of Two Drug Regimens in the Treatment of Severe Disease Activity Rheumatoid Arthritis
- 药学院－已发表论文 
目的 对重度疾病活动度类风湿关节炎患者用两种药物治疗方案的治疗效果进行探讨分析。方法 随机抽取本院2015年6月—2016年6月收治的40例重度疾病活动度类风湿关节炎的患者作为研究对象,并将其分为对照组和实验组各20例,对照组采用来氟米特联合甲氨蝶呤进行治疗,实验组在此基础上加入沙利度胺进行治疗,对两组的治疗效果进行对比分析。结果 实验组的治疗效果优于对照组的治疗效果,关节肿胀等不良反应均得到了有效的改善,差异具有统计学意义（P〈0.05）。结论 三种药物联合的治疗效果优于两种药物联合的治疗效果。Objective To investigate the effectiveness of two drug regimens in patients with severe disease activity rheumatoid arthritis. Methods 40 cases of severe disease activity rheumatoid arthritis patients were randomly selected in our hospital from June 2015 to June 2016 as the research object, and divided into control group and experimental group, 20 patients in control group were treated with leflunomide combined with methotrexate treatment, on the basis, the experimental group adding thalidomide for treatment, and the therapeutic effect of the two groups was comparative analyszed. Results The treatment effect of the experimental group was obviously better than that of the control group, and the adverse reactions such as swelling of joints were improved effectively, the difference was statistically significant （P 〈 0.05）. Conclusion The combined effect of the three drugs is obviously better than that of the two drugs.