Observation Clinical Efficacy of Ornithine Aspartate for Injection Combined with Lactulose Oral Solution in Treatment of Hepatic Encephalopathy
- 药学院－已发表论文 
目的 观察注射用门冬氨酸鸟氨酸联合乳果糖口服液治疗肝性脑病患者的临床疗效。方法 将84例重型肝炎或肝硬化并发肝性脑病患者随机分为观察组和对照组各42例。观察组给予注射用门冬氨酸鸟氨酸静脉滴注,乳果糖口服液灌肠;对照组给予精氨酸注射液静脉滴注,0.9%氯化钠注射液灌肠,两组疗程均为7d。观察患者治疗前后的临床症状体征、不良反应、肝肾功能指标及血氨水平,比较临床疗效变化。结果观察组总有效率92.86%,对照组总有效率76.19%,差异有统计学意义（P〈0.05）;治疗后观察组患者的ALT、TBil及血氨水平比对照组低（P〈0.05,P〈0.01）,差异显著。结论 注射用门冬氨酸鸟氨酸联合乳果糖口服液对改善肝功能、治疗肝性脑病有显著的临床疗效,且不良反应较少,具有临床推广价值。OBJECTIVE To observe the therapeutic effects of Ornithine Aspartate for Injection and Lactulose Oral Solution on hepatic encephalopathy. METHODS 84 cases of patients with hepatic encephalopathy due to se- vere hepatitis or liver cirrhosis were randomly divided into the observation group and controlled group with 42 cases of each group. The observation group was treated Ornithine Aspartate for Injection by intravenous drip and Lactulose O- ral Solution by clean sausage, the controlled group was treated with Arginine Hydrochloride Injection by intravenous drip and 0. 9% Sodium Chloride Injection by clean sausage, Course of the two groups were 7 days. The clinical symp- toms, signs, adverse drug reactions, hepatic function tests and blood ammonia were observed before and after treat- ment,the clinical effect of the two groups was compared. RESULTS The total effective rate was 92. 86% for the observation group and 76. 19% for the controlled group, the clinical efficacy of the observation group was better than that of the controlled group （P 〈 0. 05 ）. After treatment, the ALT, TBil and blood ammonia level of the observation group were significantly lower than those in the controlled group（P 〈 0. 05, P 〈 0. 01 ）. CONCLUSION Ornithine Aspartate for Injection combined with Lactulose Oral Solution has good clinical efficacy in improving hepatic function and hepatic encephalopathy with fewer adverse reactions ,which is worth promotion in clinic.