Show simple item record

dc.contributor.author李玉席
dc.contributor.author李俊宏
dc.contributor.author周大旺
dc.date.accessioned2018-11-26T08:28:52Z
dc.date.available2018-11-26T08:28:52Z
dc.date.issued2017-07-20
dc.identifier.citation遗传,2017,(7):607-616
dc.identifier.issn0253-9772
dc.identifier.other10.16288/j.yczz.17-064
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/165238
dc.description.abstract肝脏是人体最重要的器官之一,乙肝等病毒性与酒精等非病毒性因素诱发的肝损伤引起肝脏功能衰竭、再生重塑障碍、肝癌等疾病是我国重大社会健康问题,因此,; 研究肝脏稳态的调控机制对肝病的预防和临床治疗至关重要。Hippo信号通路参与了哺乳动物多种细胞和器官的稳态调控。最近研究表明,Hippo信号通路; 在肝脏发育、肝细胞命运决定、肝脏再生和癌症发生发展等过程中都发挥了非常重要的作用。因此,Hippo信号通路可成为肝脏相关疾病的治疗提供了新的靶点; 。本文综述了Hippo信号通路与肝脏稳态调控的相关研究及最新进展,以期为研究肝脏发育和肝脏相关疾病的治疗提供新的思路和策略。
dc.description.abstractLiver cancer and diseases have become the leading cause of deaths in; China. Liver diseases including liver failure and liver cancer can be; genetic or caused by a variety of factors that damage the liver, such as; viruses and alcohol overdose. However, the underlying mechanisms that; maintain liver homeostasis remain unclear. Recent studies show that the; Hippo signaling pathway plays a critical role in maintaining liver; tissue homeostasis. Dysregulation of the Hippo signaling pathway impairs; liver regeneration and remarkly enhances liver overgrowth and; tumorigenesis. In this review, we summarize recent progresses on the; roles and regulation mechanisms of the Hippo signaling pathway in liver; development and diseases.
dc.description.sponsorship国家自然科学基金项目
dc.language.isozh_CN
dc.subject肝脏发育
dc.subject肝癌
dc.subject肝再生
dc.subjectHippo/Yap
dc.subjectHippo/Yap
dc.subjectliver development
dc.subjectliver cancer
dc.subjectliver
dc.subjectregeneration
dc.titleHippo信号通路与肝脏稳态调控及疾病发生
dc.title.alternativeHippo signaling pathway in liver tissue homeostasis
dc.typeArticle


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record