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治疗性抗体半衰期改造研究进展
Advance in Research on Antibody Half-Life Related Engineering

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治疗性抗体半衰期改造研究进展.pdf (475.5Kb)
Date
2017
Author
陈静
康赐明
罗文新
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  • 生命科学-已发表论文 [5877]
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Abstract
随着治疗性单克隆抗体在临床治疗方面发挥的作用日益突显,其全球药物市场所占份额和研发投入均在逐年增加。除了抗体新药的开发,抗体药物效力和安全性相关; 的基因工程改造也越来越受到重视。在这些基因工程改造中,抗体半衰期改造已成为近年来研究的热点之一。对几种抗体半衰期改造技术进行了介绍,并简要描述了; 半衰期改造后抗体的临床研究现状。
 
Withthe growing development of therapeutic monoclonal antibodies in the; clinical treatment,the market share and research cost of antibody drugs; are increasing by years. In addition to the novel antibody drug; development,the antibody engineering on efficacy and safety has been; more strongly desired. Among theseengineering technologies, antibody; half-life related engineeringhas been popularly used in improving; antibody pharmacokinetic properties in recent years. Several kinds of; antibody half-life modification methods are briefly described,as well as; to their current status in clinical research.
 
Citation
中国生物工程杂志,2017,(5):87-96
URI
https://dspace.xmu.edu.cn/handle/2288/165195

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