Functions of Non-coding Small RNA in Pathogenic Bacteriaand Its New Methodology
- 公共卫生－已发表论文 
细菌中的非编码小RNA(small; RNA,sRNA)作为一种靶向调控分子在细胞生理代谢过程中具有重要作用。sRNA作用于特定靶标,调控基因的表达。大肠杆菌大约有100种sRNA,; 其中1 /3; sRNA需要伴侣蛋白Hfq的介导。病原细菌中sRNA分子如何调控致病基因的表达,目前研究仍处于初级阶段。本文将从生物膜形成、细菌耐药性以及对宿主; 的影响等方面,结合新颖的sRNA的研究方法,综述sRNA在调控代谢网络及控制病原菌致病性方面的作用。The small non-coding RNA as a special targeting regulator plays a key; role in cell metabolism process for bacteria. sRNAs interplay with; specific targets to regulate gene expression. In Escherichia coli, there; are about 100 sRNAs have been experimentally confirmed, in which; approximately one-third interact with sRNA chaperone Hfq. For pathogenic; bacteria,regulation of the expression of virulence genes mediated by; sRNAs is still in its initial stage to date and it needs to study deeply; and pertinently. Based on this,the article focus on the roles of sRNAs; in biofilm formation,bacterial resistance,physiology and the effect on; hosts,and is combined with novel methods simultaneously to elaborate the; function of sRNAs in the regulation of the metabolic network and the; control of bacterial pathogenesis.