Development of interleukin-21 as a therapeutic drug
- 公共卫生－已发表论文 
白细胞介素21; (IL-21)是一种具有多效免疫调节活性的细胞因子,参与先天性免疫反应和适应性免疫反应的多个环节,与自身免疫性疾病、肿瘤、病毒感染等疾病的发病过; 程相关。研究表明,在动物模型中通过增强或抑制IL-21的生物学功能对多种疾病具有治疗意义,多项以重组人IL-21为受试药物的临床试验已经开展。本; 文就IL-21的生物学功能,以及IL-21作为生化药物在临床治疗中的研究进展和应用前景进行阐述。Interleukin-21 (IL-21) is a cytokine with broad pleiotropic actions that; plays an important role in both innate and adaptive immune responses.; IL-21 participates in pathogenesis processes of many diseases, such as; autoimmune disease, tumor, virus infections and so on. Enhancing or; inhibiting the activity of IL-21 has shown to have certain therapeutic; effects in animal models of a wide range of diseases. Various clinical; trials using recombinant human IL-21 as drug candidates are on-going; towards the development of IL-21 as a therapeutic drug. This article; reviewed the biological function and research progress and application; prospect of IL-21 as a biochemical drug in clinical treatment.