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dc.contributor.author陈香平
dc.contributor.author黄长江
dc.contributor.author陈元红
dc.contributor.author刘滨
dc.contributor.author刘翠平
dc.contributor.author朱亚先
dc.contributor.author张勇
dc.date.accessioned2018-11-26T07:02:49Z
dc.date.available2018-11-26T07:02:49Z
dc.date.issued2017
dc.identifier.citation生态毒理学报,2017,(3):309-316
dc.identifier.issn1673-5897
dc.identifier.other10.7524/AJE.1673-5897.20161109001
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/161978
dc.description.abstract以斑马鱼(Danio rerio)为研究对象,探讨铅(Pb); 、得克隆(DP)及二者联合急性暴露对斑马鱼胚胎的神经毒性作用。结果表明,Pb(5、20 mug·L~(-1))和DP(15、60; mug·L~(-1))单独暴露均会引起斑马鱼自主运动频率增加,触摸反应能力和自由游泳活力下降,并且抑制初级运动神经元的生长,加剧尾部细胞凋亡。但; 与20 mug·L~(-1) Pb单独暴露相比,高剂量联合暴露(20 mug·L~(-1) Pb + 60 mug·L~(-1); DP)使斑马鱼的自主运动频率显著降低(P < 0.05),触摸反应能力和自由游泳活力显著增强(P <; 0.05),初级运动神经元轴突长度显著增加(P < 0.05),尾部细胞凋亡减少。与5 mug·L~(-1); Pb单独暴露相比,低剂量联合暴露(5 mug·L~(-1) Pb + 15 mug·L~(-1) DP)也显著减少斑马鱼尾部的细胞凋亡(P <; 0.05); 。上述结果表明,Pb或DP单独暴露对斑马鱼均可引起神经毒性作用;但二者联合暴露对斑马鱼自主运动、触摸反应以及自由游泳活力的影响则表现为拮抗作用。
dc.description.abstractNeurotoxic effects of acute exposure to lead (Pb) or Dechlorane Plus; (DP),or both were investigated using zebrafish (Danio rerio) embryos.; Results showed that exposure to Pb (5,20 mug·L~(-1)) or DP (15,60 mug·; L-1) alone increased spontaneous movement,decreased touch response and; free-swimming activity,inhibited axonal growth of primary motoneuron and; induced cell apoptosis in zebrafish embryos. Co-exposure to 20; mug·L~(-1) Pb and 60 mug·L~(-1) DP significantly decreased spontaneous; movement (P < 0.05),enhanced touch response and free-swimming activity; (P < 0.05),increased axonal length of primary motoneuron (P < 0.05) and; reduced cell apoptosis in zebrafish when compared to 20 mug·L~(-1) Pb; exposure alone. Co-exposure to 5 mug·L~(-1) Pb and 15 mug·L~(-1) DP also; significantly decreased cell apoptosis on the tail region when compared; to 5 mug·L~(-1) Pb exposure alone (P < 0.05). These results demonstrated; that Pb or DP exposure alone could induce neurobehavioral toxicity in; zebrafish, but Pb and DP co-exposure had antagonistic effects on; spontaneous movements,touch response and free swimming activity.
dc.description.sponsorship国家自然科学基金项目; 高等学校博士学科点专项科研基金
dc.language.isozh_CN
dc.subject
dc.subject得克隆
dc.subject斑马鱼
dc.subject胚胎
dc.subject神经毒性
dc.subject联合暴露
dc.subjectlead
dc.subjectDechlorane Plus
dc.subjectzebrafish
dc.subjectembryo
dc.subjectneurotoxicity
dc.subjectco-exposure
dc.title铅和得克隆联合暴露对斑马鱼胚胎的神经毒性作用
dc.title.alternativeNeurotoxic Effects of Co-exposure to Lead and Dechlorane Plus on Zebrafish (Danio rerio) Embryos
dc.typeArticle


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