Advances in bacterial iron homeostasis and antibiotics killing mechanism
- 公共卫生－已发表论文 
传统研究认为不同种类的抗生素有其各自不同的杀菌途径,然而近年人们发现了一条抗生素杀菌的共用通路,那就是当细菌细胞受到抗生素致死性刺激时,呼吸链代谢异常产生大量活性氧簇(ROS),而铁离子对ROS介导的杀菌至关重要。本文参阅近年来国内外研究结果,介绍了铁吸收、储存和利用有关的细菌铁代谢系统及其调控机制,重点讨论铁离子的调控及其与抗生素介导的ROS形成的相互作用关系。对于细菌耐药机制的研究与寻找新型药物作用靶点,探索有效控制手段和开发新药有重要意义。Previous research suggested that different antibiotics kill bacteria via various targets or mechanisms. However, recent study indicated that a common mechanism might be shared by most bactericidal antibiotics. When bacteria suffered lethal stress by antibiotics, reactive oxygen species(ROS) was induced by abnormal respiratory chain reaction in which iron played a key role. By reviewing current research progress regarding antibiotic resistance and iron related proteins in bacteria, including the iron absorbing, storage and consumption system in bacteria, this paper will mainly discuss the possible linkage/interaction between the regulation of ferrous ion and ROS induced by antibiotics. This common bacterial killing mechanism will have a significant impact on the future research for drugresistance, drug target screening, infection controlling and novel drug design.