Effect of Photodynamic Therapy on Primary Liver Cancer and its Clinical Significance
- 医学院－已发表论文 
目的 探讨光化学疗法 (PCT)治疗中晚期原发性肝癌的疗效及临床意义。 方法 15例中晚期原发性肝癌患者应用光化学疗法治疗 ,并在治疗前后分别取肝组织进行病理组织学观察、免疫组织化学 (p5 3、p2 1、PC NA)分析及疗效评价。 结果 患者治疗后显示 ,肝癌细胞广泛坏死 ,瘤体明显缩小 ,癌周纤维组织增生胶原化 ;p5 3、p2 1、PCNA均显示阳性表达率降低与病理组织学改变平行一致 ;治疗前后比较差异有极显著性 (P <0 0 1)。随访 11例患者中 ,有 7例生存期超过 2年 ,最长 1例存活 5年。 结论 光化学疗法治疗原发性肝细胞肝癌可以提高患者的生存率 ,有望成为肝癌的一种新的辅助治疗方法。Objective To investigate the effect of photochemotherapy(PCT) on medium-later period primary liver cancer(PLC) and its clinical significance. Methods Fifteen patients with PLC were selected and received PCT. The liver tissue samples were collected before and after the treatment, and subsequently used for histopathologic examination. Immunohistochemistry was performed to analysis the expression change of p53, p21 and PCNA. Results After PCT, the liver cancer revealed extensive necrotic injury and the tumor decreased significantly in size. The fibrous tissue adjacent to the tumor proliferated and became collagenous. The positive expression of p53, p21 and PCNA decreased, which was consistent with the histopathologic change, there were significantly different before and after the treatment(P<0.01). In eleven follow-up cases, among which one had ever lived the longest 5 years and 7 had survived for more than 2 years. Conclusion Photodynamic therapy could improve the survival rate of patients with PLC. PCT may be a new assisted therapy for liver cancer.