Show simple item record

dc.contributor.authorGao, Jingchun
dc.contributor.authorYang, Xiangjun
dc.contributor.author杨湘军
dc.contributor.authorYin, Ping
dc.contributor.authorHu, Wenfeng
dc.contributor.authorLiao, Hongfeng
dc.contributor.authorMiao, Zhihui
dc.contributor.authorPan, Chao
dc.contributor.authorLi, Na
dc.date.accessioned2013-04-16T07:33:13Z
dc.date.available2013-04-16T07:33:13Z
dc.date.issued2012-04
dc.identifier.citationINTERNATIONAL JOURNAL OF ONCOLOGY,2012,40(4):1203-1209zh_CN
dc.identifier.issn1019-6439
dc.identifier.urihttp://dx.doi.org/10.3892/ijo.2011.1293
dc.identifier.uriWOS:000301637800036
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/15651
dc.description.abstractMinibrain-related kinase (Mirk) is a serine/threonine kinase which is also known as the dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1B). It is known that Dyrk1A, the closest family member to Mirk/Dyrk1B can mediate cellular localization of mammalian forkhead subclass O (FoxO1), a transcription factor, although the effect of Mirk/Dyrk1B on Foxes factors remains to be defined. In this study, we showed that Mirk/Dyrk1B protein was overexpressed in 5 of 8 ovarian cancer cell lines and negatively correlated with the protein level of FoxO factors (FoxO1+FoxO3A). Knockdown of Mirk by small interfering RNA (siRNA) resulted in cell apoptosis and sensitized cells to cisplatin accompanied by nuclear translocation of FoxO1 and/or FoxO3A as well as increased Bim, TRADD, cleaved caspase-3 and PARP. Furthermore, combined siRNAs of Mirk with FoxO1 and/or FoxO3A led to fewer apoptotic cells and cisplatin sensitivity compared to Mirk siRNA alone, suggesting that FoxO is involved in Mirk-mediated cell survival and chemosensitivity of ovarian cancer. Taken together, Mirk/Dyrk1B plays an important role in ovarian cancer cell survival through modulating FoxO translocation and may be a novel therapeutic target for ovarian cancer.zh_CN
dc.description.sponsorshipNational Natural Science Foundation of China [81172457]; Natural Science Foundation of Fujian Province, P.R. China [2010J01236]zh_CN
dc.language.isoenzh_CN
dc.publisherSPANDIDOS PUBL LTDzh_CN
dc.subjectminibrain-related kinase/dual specificity tyrosine-phosphorylation-regulated kinase 1Bzh_CN
dc.subjectforkhead subclass Ozh_CN
dc.subjectapoptosiszh_CN
dc.subjectovarian cancerzh_CN
dc.titleThe involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancerzh_CN
dc.typeArticlezh_CN


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record