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dc.contributor.authorHuang, Lixing
dc.contributor.authorWang, Chonggang
dc.contributor.author王重刚
dc.contributor.authorZhang, Youyu
dc.contributor.authorLi, Jian
dc.contributor.authorZhong, Yuanfu
dc.contributor.authorZhou, Yulin
dc.contributor.authorChen, Yixin
dc.contributor.author陈奕欣
dc.contributor.authorZuo, Zhenghong
dc.contributor.author左正宏
dc.date.accessioned2013-04-16T02:55:46Z
dc.date.available2013-04-16T02:55:46Z
dc.date.issued2012-04
dc.identifier.citationCHEMOSPHERE,2012,87(4):369-375zh_CN
dc.identifier.issn0045-6535
dc.identifier.urihttp://dx.doi.org/10.1016/j.chemosphere.2011.12.026
dc.identifier.uriWOS:000302045600011
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/15642
dc.description.abstractIt is reported that the most abundant polycyclic aromatic hydrocarbons (PAHs) in weathered crude oils are cardiotoxic. However, the action mechanism of PAHs on vertebrate cardiovascular development and disease is unclear. In the present study, the cardiac morphology and functioning of zebrafish embryos exposed to benzo[a]pyrene [B(a)P], as a high-ring PAHs, for 72 h were observed and determined. The results showed that B(a)P exposure resulted in cardiac developmental defects in zebrafish embryos. Significant changes in expression level of multiple genes potentially critical for regulating the B(a)P-induced cardiovascular developmental defects were also found. A gene network regulating cardiac development perturbed by B(a)P exposure was identified and established by computational analysis and employment of some databases. The information from the network could provide a clue for further mechanistic studies explaining molecular events regulating B(a)P-mediated cardiovascular defects and consequences. (C) 2011 Elsevier Ltd. All rights reserved.zh_CN
dc.description.sponsorshipNational Natural Science Foundation of China [20877064]; Natural Scientific Fund of Fujian Province, China [2009J01225]; program for Changjiang Scholars and Innovative Research Team in University [IRT0941]; National Foundation for fostering talents of basic science [J1030626]zh_CN
dc.language.isoenzh_CN
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDzh_CN
dc.subjectB(a)Pzh_CN
dc.subjectCardiac toxicityzh_CN
dc.subjectEmbryonic developmentzh_CN
dc.subjectGene regulatory networkszh_CN
dc.subjectMicroarrayzh_CN
dc.subjectZebrafishzh_CN
dc.titleBenzo[a]pyrene exposure influences the cardiac development and the expression of cardiovascular relative genes in zebrafish (Danio rerio) embryoszh_CN
dc.typeArticlezh_CN


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