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dc.contributor.authorZhao, Zengxia
dc.contributor.authorHan, Yuning
dc.contributor.authorLin, Chenghong
dc.contributor.authorHu, Dong
dc.contributor.authorWang, Fang
dc.contributor.authorChen, Xiaolan
dc.contributor.authorChen, Zhong
dc.contributor.author陈忠
dc.contributor.authorZheng, Nanfeng
dc.contributor.author郑南峰
dc.date.accessioned2013-04-15T07:33:26Z
dc.date.available2013-04-15T07:33:26Z
dc.date.issued2012-03
dc.identifier.citationCHEMISTRY-AN ASIAN JOURNAL,2012,7(4):830-837zh_CN
dc.identifier.issn1861-4728
dc.identifier.urihttp://dx.doi.org/10.1002/asia.201100879
dc.identifier.uriWOS:000302159900027
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/15626
dc.description.abstractLanthanide-doped upconversion nanoparticles (UCNPs) have attracted considerable attention for their application in biomedicine. Here, silica-coated NaGdF4:Yb,Er/NaGdF4 nanoparticles with a tetrasubstituted carboxy aluminum phthalocyanine (AlC4Pc) photosensitizer covalently incorporated inside the silica shells were prepared and applied in the photodynamic therapy (PDT) and magnetic resonance imaging (MRI) of cancer cells. These UCNP@SiO2(AlC4Pc) nanoparticles were uniform in size, stable against photosensitizer leaching, and highly efficient in photogenerating cytotoxic singlet oxygen under near-infrared (NIR) light. In vitro studies indicated that these nanoparticles could effectively kill cancer cells upon NIR irradiation. Moreover, the nanoparticles also demonstrated good MR contrast, both in aqueous solution and inside cells. This is the first time that NaGdF4:Yb,Er/NaGdF4 upconversion-nanocrystal-based multifunctional nanomaterials have been synthesized and applied in PDT. Our results show that these multifunctional nanoparticles are very promising for applications in versatile imaging diagnosis and as a therapy tool in biomedical engineering.zh_CN
dc.description.sponsorshipNSFC [21101131, 21021061, 20925103, 20871100]; Fok Ying Tung Education Foundation [121011]; NSF of Fujian Province [2009J06005]; Fundamental Research Funds for the Central Universities [2010121015]; Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry; NFFTBS [J1030415]zh_CN
dc.language.isoenzh_CN
dc.publisherWILEY-V C H VERLAG GMBHzh_CN
dc.subjectcancerzh_CN
dc.subjectlanthanideszh_CN
dc.subjectmagnetic resonance imagingzh_CN
dc.subjectnanoparticleszh_CN
dc.subjectphotodynamic therapyzh_CN
dc.titleMultifunctional Core-Shell Upconverting Nanoparticles for Imaging and Photodynamic Therapy of Liver Cancer Cellszh_CN
dc.typeArticlezh_CN


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