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dc.contributor.authorChen, Xiaoli
dc.contributor.author陈晓莉
dc.contributor.authorLv, Haiyan
dc.contributor.authorYe, Min
dc.contributor.authorWang, Shengyu
dc.contributor.authorNi, Erru
dc.contributor.authorZeng, Fanwei
dc.contributor.authorCao, Chang
dc.contributor.authorLuo, Fanghong
dc.contributor.authorYan, Jianghua
dc.date.accessioned2013-04-11T02:15:32Z
dc.date.available2013-04-11T02:15:32Z
dc.date.issued2012-04-15
dc.identifier.citationINTERNATIONAL JOURNAL OF PHARMACEUTICS,2012,426:248-255zh_CN
dc.identifier.issn0378-5173
dc.identifier.urihttp://dx.doi.org/10.1016/j.ijpharm.2012.01.043
dc.identifier.uriWOS:000302364300028
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/15566
dc.description.abstractThe goal of this study was to develop novel embolic nanoparticles for targeted tumor therapy with dual targeting: magnetic field-guided and peptide-directed targeting. The embolic nanoparticles SP5.2/tTF-OCMCs-SPIO-NPs were prepared by surface-modifying of superparamagnetic iron oxide nanoparticles (SPIO-NPs) with o-carboxymethylchitosans (OCMCs) and SP5.2/tTF (SP5.2: a peptide binding to VEGFR-1; tTF: truncated tissue factor) to improve their stability and to target over-expressing VEGFR-1 cells. The physicochemical characterization results showed that the OCMCs-SPIO-NPs have a spherical or ellipsoidal morphology with an average diameter of 10-20 nm. And they possess magnetism with a saturation magnetization of 66.1 emu/g, negligible coercivity and remanence at room temperature. In addition, the confocal microscopy, Prussian blue staining and FX activation analysis respectively demonstrated the peptide-directed targeting, magnetic field-guided targeted and blood coagulation activity of the SP5.2/tTF-OCMCs-SPIO-NPs. These properties separately belong to SP5.2, Fe3O4 and tTF moieties of the SP5.2/tTF-OCMCs-SPIO-NPs. Thus these SP5.2/tTF-OCMCs-SPIO-NPs with double-targeting function should have a potential application in embolization therapy of tumor blood vessels. (C) 2012 Elsevier B. V. All rights reserved.zh_CN
dc.description.sponsorshipNational Natural Science Foundation of China [30973485, 81172970]zh_CN
dc.language.isoenzh_CN
dc.publisherELSEVIER SCIENCE BVzh_CN
dc.subjectMagnetic nanoparticleszh_CN
dc.subjectSuperparamagneticzh_CN
dc.subjecto-Carboxymethylchitosanzh_CN
dc.subjectTruncated tissue factorzh_CN
dc.subjectTumor targetingzh_CN
dc.titleNovel superparamagnetic iron oxide nanoparticles for tumor embolization application: Preparation, characterization and double targetingzh_CN
dc.typeArticlezh_CN


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