Study on the Two-Component-Determined Circulating Immune Complexes in Hyperthyroidism
- 生命科学－已发表论文 
采用捕捉法 EL ISA,检测 10 8例甲亢患者的抗体 /补体类双特异性免疫复合物 (Ig- C3- TCIC)和抗体 /抗体类双特异性免疫复合物 (Ig/Ig- TCIC) .结果发现 ,甲亢患者除了 C3/Ig A- TCIC含量显著高于健康人 ,C3/Ig M- TCIC与健康人无显著性差异外 ,Ig M/C3- TCIC、Ig G/C3- TCIC、Ig A/C3-TCIC和 C3/Ig G- TCIC的含量均显著低于健康人 ;各类 Ig/Ig- TCIC含量 ,除 Ig A/Ig M- TCIC与健康人无显著差异外 ,其余均显著高于健康人 .结果表明 ,甲亢患者排除“异己”抗原的能力低下 ,而免疫调节水平紊乱 ,从而出现过高的免疫应答 .也证明甲亢患者存在整体的体液和细胞免疫紊乱Capture ELISA methods were used to detect two component determined circulating immune complexes(TCIC) of Ig C3 and Ig/Ig (Ig C3 TCIC and Ig/Ig TCIC) in 108 cases of hyperthyroidism. It was found that IgM/C3 TCIC?IgG/C3 TCIC?IgA/C3 TCIC and C3/IgG TCIC were significantly lower, although the amount of C3/IgA TCIC was significantly higher in patients with hyperthyroidism than that in healthy controls,and there was no difference of C3/IgM TCIC between them. Except for IgA/IgM TCIC, furthermore, the levels of Ig/Ig TCIC were significantly higher in the patients than in the control. These findings suggest that the patients have weak function in excluding "nonego" antigens. Moreover, there is immune response over normality in the patients because of the disorder of immuno regulation. In the meanwhile, our result indicates that there is entirely humoral and cellular disorder in patients with this disease.