Pyrene exposure influences the craniofacial cartilage development of Sebastiscus marmoratus embryos
Date
2012-06Author
Shi, Xiao
He, Chengyong
Zuo, Zhenghong
左正宏
Li, Ruixia
Chen, Donglei
Chen, Rong
陈荣
Wang, Chonggang
王重刚
Collections
- 生命科学-已发表论文 [5901]
Abstract
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants, which are known carcinogens and teratogens. However, the toxicity of PAHs during skeletal development and the mechanism involved are not completely clear. In the present study, rockfish (Sebastiscus marmoratus) embryos were exposed to pyrene (Pyr) for 7 days at 0.5, 5 and 50 nM which resulted in craniofacial skeleton deformities. Pyr exposure for 6 days reduced the expression of PCNA, Col2a1 and Sox9 in the craniofacial skeleton revealed using in situ hybridization. These results suggest that Pyr exposure impairs skeleton development via disrupting the proliferation of the chondrocytes. At the same time, Pyr exposure reduced the expression of lox1 and inhibited the activity of lysyl oxidase, which is the key enzyme controlling the collagen cross-linking, and which might therefore have been one of the reasons for the deformative Meckel's cartilage (lower jaw). (C) 2012 Elsevier Ltd. All rights reserved.
Citation
MARINE ENVIRONMENTAL RESEARCH,2012,77:30-34URI
http://dx.doi.org/10.1016/j.marenvres.2012.01.003WOS:000304296700005
https://dspace.xmu.edu.cn/handle/2288/15408