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A Monoclonal Antibody Against the Catalytic Domain of PTP1B

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A Monoclonal Antibody Against the Catalytic Domain of PTP1B.htm (407bytes)
Date
2012-06
Author
Zeng, Fanwei
Ni, Erru
Wang, Shengyu
Lv, Sha
Cao, Chang
Zhang, Haipeng
Lv, Haiyan
Chen, Xiaoli
Yan, Jianghua
Luo, Fanghong
罗芳洪
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  • 医学院-已发表论文 [2663]
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Abstract
Protein tyrosine phosphatase 1B (PTP1B), a member of the protein tyrosine phosphatase (PTP) family, plays a crucial role in metabolic signaling, with insulin and leptin signaling being well studied. New evidence indicates that PTP1B is also involved in cancer. In the present study, we report on the establishment of a monoclonal antibody specific for catalytic domain of PTP1B (PTP1Bc) generated through the hybridoma method. The monoclonal antibody is measured to have a titer of 4.1 x 10(6) against PTP1Bc in indirect ELISA. Western blot and immunofluorescent analyses indicated that this antibody can specifically combine native PTP1B in MDA-MB-231 and MDA-MB-453 cells. This monoclonal antibody against PTP1Bc can help enhance the understanding of PTP1B-related physiological and pathological mechanisms and may act as a therapeutic agent for diabetes, obesity, and cancer in the future.
Citation
HYBRIDOMA,2012,31(3):209-213
URI
http://dx.doi.org/10.1089/hyb.2011.0115
WOS:000305947600010
https://dspace.xmu.edu.cn/handle/2288/15344

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