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dc.contributor.authorWu, Xing-Xing
dc.contributor.author吴星星
dc.contributor.authorShuai, J. W.
dc.date.accessioned2013-03-22T01:13:55Z
dc.date.available2013-03-22T01:13:55Z
dc.date.issued2012-06-13
dc.identifier.citationPHYSICAL REVIEW E,2012,85(6)zh_CN
dc.identifier.issn1539-3755
dc.identifier.urihttp://dx.doi.org/10.1103/PhysRevE.85.061911
dc.identifier.uriWOS:000305256300002
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/15266
dc.description.abstractExperiments show a primary role of extracellular potassium concentrations in neuronal hyperexcitability and in the generation of epileptiform bursting and depolarization blocks without synaptic mechanisms. We adopt a physiologically relevant hippocampal CA1 neuron model in a zero-calcium condition to better understand the function of extracellular potassium in neuronal seizurelike activities. The model neuron is surrounded by interstitial space in which potassium ions are able to accumulate. Potassium currents, Na+-K+ pumps, glial buffering, and ion diffusion are regulatory mechanisms of extracellular potassium. We also consider a reduced model with a fixed potassium concentration. The bifurcation structure and spiking frequency of the two models are studied. We show that, besides hyperexcitability and bursting pattern modulation, the potassium dynamics can induce not only bistability but also tristability of different firing patterns. Our results reveal the emergence of the complex behavior of multistability due to the dynamical [K+](o) modulation on neuronal activities.zh_CN
dc.description.sponsorshipNational Science Foundation of China [30970970]; China National Funds for Distinguished Young Scientists [11125419]zh_CN
dc.language.isoenzh_CN
dc.publisherAMER PHYSICAL SOCzh_CN
dc.subjectSPREADING DEPRESSIONzh_CN
dc.subjectINTERSTITIAL SPACEzh_CN
dc.subjectHIPPOCAMPAL SLICESzh_CN
dc.subjectIN-VIVOzh_CN
dc.subjectSEIZURESzh_CN
dc.subjectCALCIUMzh_CN
dc.subjectOSCILLATIONSzh_CN
dc.subjectSODIUMzh_CN
dc.subjectFLUIDzh_CN
dc.subjectSLOWzh_CN
dc.titleMultistability in a neuron model with extracellular potassium dynamicszh_CN
dc.typeArticlezh_CN


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