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dc.contributor.authorLi, Ping
dc.contributor.authorZhong, Yuanfu
dc.contributor.authorJiang, Xiaoming
dc.contributor.authorWang, Chonggang
dc.contributor.author王重刚
dc.contributor.authorZuo, Zhenghong
dc.contributor.author左正宏
dc.contributor.authorSha, Aiguo
dc.date.accessioned2013-03-19T02:11:42Z
dc.date.available2013-03-19T02:11:42Z
dc.date.issued2012-07
dc.identifier.citationBIOLOGICAL TRACE ELEMENT RESEARCH,2012,148(1):1-6zh_CN
dc.identifier.issn0163-4984
dc.identifier.urihttp://dx.doi.org/10.1007/s12011-012-9335-7
dc.identifier.uriWOS:000305128400001
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/15165
dc.description.abstractThe aim of the current study was to assess relationships between multiple metals burden in human seminal plasma and semen quality parameters. Levels of five metals (lead, manganese, copper, arsenic, and selenium) in human seminal plasma were determined by inductively coupled plasma mass spectrometry (ICP-MS), and the correlations between the metal concentrations and semen parameters (sperm concentration, sperm motility rate, and sperm morphology) were analyzed. The activities of acid phosphatase (ACP) and of alpha-glucosidase in human seminal plasma were also determined. Of the 100 subjects, 21 had fertility problems according to the World Health Organization criteria and were designated as "abnormal group." Significant inverse correlations were found between the concentrations of Cu, As, Pb, and the sperm concentrations (r (Cu) = -0.312, P (Cu) = 0.029; r (As) = -0.328, P (As) = 0.021; r (Pb) = -0.377, P (Pb) = 0.008). Moreover, the Cu, Mn, and Se concentrations were significantly higher in the abnormal group than that in the normal group (P (Cu) = 0.024, P (Mn) = 0.002, P (Se) = 0.002). The ACP activity was significantly higher in the normal group than that in the abnormal group (P = 0.021). We also found a significantly negative correlation between alpha-glucosidase activity and the levels of As (r = -0.367, P = 0.023). These findings provide evidence for relationships between human semen quality and metal exposures. These relationships are consistent with animal data, but additional human and mechanistic studies are needed.zh_CN
dc.description.sponsorshipFundamental Research Funds for the Central Universities [2010121024]; National Foundation for fostering talents of basic science [J1030626]zh_CN
dc.language.isoenzh_CN
dc.publisherHUMANA PRESS INCzh_CN
dc.subjectHuman semen qualityzh_CN
dc.subjectMetalszh_CN
dc.subjectAcid phosphatasezh_CN
dc.subjectalpha-Glucosidasezh_CN
dc.titleSeminal Plasma Metals Concentration with Respect to Semen Qualityzh_CN
dc.typeArticlezh_CN


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