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dc.contributor.authorTang, Kai
dc.contributor.author唐凯
dc.contributor.authorJiao, Nianzhi
dc.contributor.author焦念志
dc.contributor.authorLiu, Keshao
dc.contributor.authorZhang, Yao
dc.contributor.author张瑶
dc.contributor.authorLi, Shuhui
dc.date.accessioned2013-03-08T07:11:12Z
dc.date.available2013-03-08T07:11:12Z
dc.date.issued2012-07-19
dc.identifier.citationPLOS ONE,2012,7(7)zh_CN
dc.identifier.issn1932-6203
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0041204
dc.identifier.uriWOS:000306956300067
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/15080
dc.description.abstractBackground: Bacteria play critical roles in marine nutrient cycles by incorporating and redistributing dissolved organic matter (DOM) and inorganic nutrients in the ocean. TonB-dependent transporter (TBDT) proteins allow Gram-negative bacteria to take up scarce resources from nutrient-limiting environments as well as siderophores, heme, vitamin B12, and recently identified carbohydrates. Thus, the characterization of TBDT distribution and functions is essential to better understand the contribution TBDT to DOM assimilation and its consequences on nutrient cycling in the environment. Methodology/Principal Findings: This study presents the distribution of encoded known and putative TBDT proteins in the genomes of microorganisms and from the Global Ocean Survey data. Using a Lek clustering algorithm and substrate specificities, the TBDT sequences were mainly classified into the following three groups: (1) DOM transporters; (2) Siderophores/Vitamins transporters; and (3) Heme/Hemophores/Iron(heme)-binding protein transporters. Diverse TBDTs were found in the genomes of oligotroph Citromicrobium bathyomarinum JL354 and Citromicrobium sp JLT1363 and were highly expressed in the stationary phase of bacterial growth. The results show that the Gammaproteobacteria and the Cytophaga-Flavobacterium-Bacteroides (CFB) group bacteria accounted for the majority of the TBDT gene pool in marine surface waters. Conclusions/Significance: The results of this study confirm the ecological importance of TBDTs in DOM assimilation for bacteria in marine environments owing to a wide range of substrate utilization potential in the ubiquitous Gammaproteobacteria and CFB group bacteria.zh_CN
dc.description.sponsorshipNSFC (Natural Science Foundation of China) [40906079]; National Basic Research Program of China [2011CB808800]; NSFC [91028001]; Public Science and Technology Research Funds Projects of Ccean [201105021]; Scientific Research Foundation for Returned Scholars, Ministry of Education of Chinazh_CN
dc.language.isoenzh_CN
dc.publisherPUBLIC LIBRARY SCIENCEzh_CN
dc.subjectACETYLGLUCOSAMINE UTILIZATION PATHWAYzh_CN
dc.subjectOUTER-MEMBRANEzh_CN
dc.subjectCOMPARATIVE GENOMICSzh_CN
dc.subjectPROTEOMIC ANALYSISzh_CN
dc.subjectACTIVE-TRANSPORTzh_CN
dc.subjectOCEANzh_CN
dc.subjectDATABASEzh_CN
dc.subjectCARBONzh_CN
dc.subjectGENESzh_CN
dc.subjectSEAzh_CN
dc.titleDistribution and Functions of TonB-Dependent Transporters in Marine Bacteria and Environments: Implications for Dissolved Organic Matter Utilizationzh_CN
dc.typeArticlezh_CN


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