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dc.contributor.authorHe, Chengyong
dc.contributor.authorWang, Chonggang
dc.contributor.author王重刚
dc.contributor.authorZhou, Yulin
dc.contributor.authorLi, Jian
dc.contributor.authorZuo, Zhenghong
dc.contributor.author左正宏
dc.date.accessioned2013-03-01T03:00:34Z
dc.date.available2013-03-01T03:00:34Z
dc.date.issued2012-08
dc.identifier.citationNEUROTOXICOLOGY,2012,33(4):758-762zh_CN
dc.identifier.issn0161-813X
dc.identifier.urihttp://dx.doi.org/10.1016/j.neuro.2012.01.002
dc.identifier.uriWOS:000307617200019
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/15017
dc.description.abstractBenzo(a)pyrene (BaP) is known to be carcinogenic and teratogenic. Several epidemiological and animal studies report that BaP causes neurological abnormalities; however, the mechanism of BaP-induced impairment of nervous system development and function, particularly in fish, remains unclear. In this study, Sebastiscus marmoratus embryos were exposed to BaP at environmental levels (0.5, 5 and 25 nmol/ L) for 7 days. The results show disruption of the cranial innervation pattern. The expression of calmodulin(CaM) and Ca2+/calmodulin dependent kinase II (CaMKII) was decreased in a dose-dependent manner. BaP exposure reduced the levels of ACh and ChAT and promoted the activity of AChE. In addition, BaP exposure decreased NO concentration in all treatments and increased the activity of NOS in the 0.5 and 5 nmol/L groups. These results suggest that BaP could decrease the expression CaM and CaMKII mRNA and NO, which would perturb the cholinergic system and disrupt nervous system development. (C) 2012 Elsevier Inc. All rights reserved.zh_CN
dc.description.sponsorshipNational Natural Science Foundation of China [20977071]; project of the Xiamen Science and Technology Program [3502Z20084024]zh_CN
dc.language.isoenzh_CN
dc.publisherELSEVIER SCIENCE BVzh_CN
dc.subjectBenzo(a)pyrenezh_CN
dc.subjectNeurodevelopmental defectzh_CN
dc.subjectAChzh_CN
dc.subjectNOzh_CN
dc.subjectCalmodulinzh_CN
dc.subjectSebastiscus marmoratuszh_CN
dc.titleEmbryonic exposure to benzo(a)pyrene influences neural development and function in rockfish (Sebastiscus marmoratus)zh_CN
dc.typeArticlezh_CN


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