Two New p-Terphenyl Derivatives from the Marine Fungal Strain Aspergillus sp AF119
- 生命科学－已发表论文 
Two new p-terphenyl derivatives (I, 2), together with six known ones (3 - 8), have been isolated from the marine fungal strain Aspergillus sp. AF119. The structures for terphyl acid (I) and terphyl diacid (2) were determined on the basis of HR Q-TOF-MS, and 1D- and 2D-NMR spectroscopic data. The in vitro cytotcxic activities of compounds I 8 were tested against human tumor cell lines HeLa, HepG-2 and MDA-MB-435; only compounds 5 8 exhibited inhibitory activity against the tested cell lines with IC50 values < 20 mu M. Moreover, compound 5 showed a mechanism of inducing cell cycle arrest and apoptosis mediated by the generation of ROS and subsequent DNA double-strand break.
CitationNATURAL PRODUCT COMMUNICATIONS，2012,7（8）;1057-1062