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dc.contributor.authorHuang, Jie
dc.contributor.authorZong, Cheng
dc.contributor.authorShen, He
dc.contributor.authorLiu, Min
dc.contributor.authorChen, Biao
dc.contributor.authorRen, Bin
dc.contributor.author任斌
dc.contributor.authorZhang, Zhijun
dc.date.accessioned2013-02-26T01:18:10Z
dc.date.available2013-02-26T01:18:10Z
dc.date.issued2012-08-20
dc.identifier.citationSMALL,2012,8(16):2577-2584zh_CN
dc.identifier.issn1613-6810
dc.identifier.urihttp://dx.doi.org/10.1002/smll.201102743
dc.identifier.uriWOS:000307390300018
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/14912
dc.description.abstractThe last few years have witnessed rapid development of biological and medical applications of graphene oxide (GO), such as drug/gene delivery, biosensing, and bioimaging. However, little is known about the cellular uptake mechanism and pathway of GO. In this work, surface-enhanced Raman scattering (SERS) spectroscopy is employed to investigate the cellular internalization of GO loaded with Au nanoparticles (NPs) by Ca Ski cells. The presence of Au NPs on the surface of GO enables detection of enhanced intrinsic Raman signals of GO inside the cell. The SERS results reveal that GO is distributed inhomogeneously inside the cell. Furthermore, internalization of Au-GO into Ca Ski cells is mainly via clathrin-mediated endocytosis, and is an energy-dependent process.zh_CN
dc.description.sponsorshipNatural Science Foundation of China [21073224]; State Key Laboratory of Physical Chemistry of Solid Surfaces of Xiamen Universityzh_CN
dc.language.isoenzh_CN
dc.publisherWILEY-V C H VERLAG GMBHzh_CN
dc.subjectGOLD NANOPARTICLESzh_CN
dc.subjectENDOCYTOSISzh_CN
dc.subjectDELIVERYzh_CN
dc.subjectSCATTERINGzh_CN
dc.subjectGRAPHITEzh_CN
dc.subjectBIOLOGYzh_CN
dc.subjectDRUGSzh_CN
dc.subjectCELLSzh_CN
dc.subjectDYESzh_CN
dc.titleMechanism of Cellular Uptake of Graphene Oxide Studied by Surface-Enhanced Raman Spectroscopyzh_CN
dc.typeArticlezh_CN


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